80681-09-0 Usage
Uses
Used in Research and Development:
L-Threonine-15N is used as a research tool for studying the metabolism and enzymatic reactions of L-Threonine. The incorporation of the nitrogen-15 isotope enables researchers to track and analyze the behavior of this essential amino acid in various biological processes.
Used in Pharmaceutical Industry:
L-Threonine-15N is used as a tracer in the development of pharmaceuticals targeting L-Threonine-related metabolic pathways. Its ability to be detected and monitored allows for the optimization of drug candidates and the evaluation of their efficacy in modulating L-Threonine metabolism.
Used in Nutritional Science:
L-Threonine-15N is used as a marker in nutritional studies to investigate the role of L-Threonine in human development and health. The isotope-labeled analog provides insights into the absorption, distribution, and utilization of this essential amino acid in the body.
Used in Food Industry:
L-Threonine-15N is used in the food industry for quality control and product development. The isotope-labeled amino acid can be used to monitor the presence and concentration of L-Threonine in food products, ensuring nutritional content and consistency.
Check Digit Verification of cas no
The CAS Registry Mumber 80681-09-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,6,8 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 80681-09:
(7*8)+(6*0)+(5*6)+(4*8)+(3*1)+(2*0)+(1*9)=130
130 % 10 = 0
So 80681-09-0 is a valid CAS Registry Number.
80681-09-0Relevant academic research and scientific papers
Syntheses of isotopically labelled L-?±-amino acids with an asymmetric centre at C-3
Harding, John R.,Hughes, Rachael A.,Kelly, Nicholas M.,Sutherland, Andrew,Willis, Christine L.
, p. 3406 - 3416 (2007/10/03)
Approaches are described to the synthesis of a series of isotopically labelled L-a-amino acids each with an asymmetric centre at C-3, including isoleucine, allo-isoleucine, threonine and allo-threonine. The methods may be simply adapted for the selective incorporation of an isotopic label at each site of L-valine including the selective labelling of either diastereotopic methyl group with carbon-13 and/or deuterium and labelling of the amine with nitrogen-15. ? The Royal Society of Chemistry 2000.
Enantioselective syntheses of α-amino-β-hydroxy acids, [15N]-L-allothreonine and [15N]-L-threonine
Sutherland, Andrew,Willis, Christine L.
, p. 1837 - 1840 (2007/10/03)
The enantioselective synthesis of [15N]-L-allothreonine from ethyl (S)-lactate via methyl (S)-3-methoxymethoxy-2-oxobutanoate 15 is described. The stereogenic centre at C-2 was established by a one-pot, dual enzyme catalysed hydrolysis of the ester (by a lipase) and reductive amination of the ketone of 15 (with leucine dehydrogenase) to give, after deprotection, [15N]-(2S,3S)-2-amino-3-hydroxybutanoic acid as a single diastereomer in 93% yield. [15N]-L-Threonine was prepared by an analogous strategy from methyl (R)-lactate using phenylalanine dehydrogenase in the reductive amination step. This approach may be simply adapted for the incorporation of deuterium and carbon-13.
