80683-08-5

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 107-19-7 propargyl alcohol 
• 479682-77-4 4-hydroxy-6-phenyl-1-(tetrahydropyran-2'-yloxy)hex-2-yne 

Downstream Products

• 36707-30-9 2-(2-phenylethyl)furan 
• 191112-45-5 2-(2'-phenylethyl)-2,5-dihydrofuran 
• 80682-98-0 (Z)-1,4-dihydroxy-6-phenylhex-2-ene 

Relevant academic research and scientific papers

Conversion of (Z)-1,4-dihydroxyalk-2-enes into 2,5-dihydrofurans and of alkane-1,4-diols into tetrahydrofurans via acid-catalysed cyclisation of the monoisoureas formed by their copper(I)-mediated reactions with dicyclohexylcarbodiimide

(Z)-1,4-dihydroxyalk-2-enes were converted into 2,5-dihydrofurans and alkane-1,4-diols were converted into tetrahydrofurans via acid-catalysed cyclisation of the monoisoureas. The reaction involved protonation of the carbodiimide by acidic phenol followed by reaction with alkanol. Pd/CaCo3-quinoline catalyst system was employed in the presence of a little triethylamine to overcome partial hydrogenolysis.

EFFICIENT TRANSFORMATION OF (Z)-BUTENE-1,4-DIOLS TO SUBSTITUTED FURANS WITH PYRIDINIUM CHLOROCHROMATE (PCC)

(Z)-2-Butene-1,4-diols were efficiently converted to the corresponding substituted furans by one step oxidation-dehydration process with pyridinium chlorochromate (PCC).