80684-63-5Relevant academic research and scientific papers
Interrupted fischer-indole intermediates via oxyarylation of alkenyl boronic acids
Wang, Heng-Yen,Anderson, Laura L.
, p. 3362 - 3365 (2013/07/26)
The oxyarylation of alkenyl boronic acids with N-arylbenzhydroxamic acids has been achieved under both copper-mediated and copper-catalyzed conditions to provide access to interrupted Fischer-indole intermediates. This transformation is believed to proceed through a copper-promoted C-O bond forming event followed by a [3,3] rearrangement. The scope of the method is described and mechanistic experiments are discussed.
ortho-Disubstituted F-Benzenes. III. Preparation of (F-Benzo)heterocyclic Compounds from F-Benzoic Acid and F-Phenol, and the Reactions of Some Intermediary F-Benzoyl- and F-Phenoxy Compounds
Inukai, Yoshinari,Oono, Yoshitsugu,Sonoda, Takaaki,Kobayashi, Hiroshi
, p. 3447 - 3452 (2007/10/02)
With the intention of achieving the selective ortho-substitution of F-benzoic acid and F-phenol via intramolecular nucleophilic cyclization, preparation of some requisite precursory F-benzoyl- and F-phenoxy compounds and their nucleophilic cyclization reactions were examined. 1,2-(F-Benz)isoxazol-3(2H)-one, 2-(p-tolyl)-1,2-(F-benz)isoxazol-3(2H)-one, 1,3-dimethyl(F-benzo)pyrimidine-2,4(1H,3H)-dione, and 1,4-(F-benz)oxazin-3(2H)-one were obtained from the respective precursory F-benzohydroxamic acid, N-(p-tolyl)-N-hydroxy-F-benzamide, N,N'-dimethyl-N-(F-benzoyl)urea, and 2-(F-phenoxy)acetohydrazide.Attempted cyclizations of 2-(F-phenoxy)acetohydroxamic acid and (F-phenoxy)acetic acid were accompanied by simultaneous ring-opening and resulted in the formation of the identical product : (2-hydroxy-F-phenoxy)acetic acid.Transamidation of ethyl F-benzoate with hydroxylamine failed to give F-benzohydroxamic acid, which was then obtained by the catalytic debenzylation of N-benzyloxy-F-benzamide.
