80706-26-9Relevant academic research and scientific papers
Preparation of 2-, 4-, 5-, and 6-aminonicotinic acid tert-butyl esters
Wright, Stephen W.
experimental part, p. 442 - 445 (2012/06/15)
Procedures are reported to prepare the tert-butyl esters of 2-aminonicotinic acid, 4-aminonicotinic acid, 5-aminonicotinic acid, and 6-aminonicotinic acid from 2-chloronicotinic acid, 4-chloronicotinic acid, 5-bromonicotinic acid, and 6-chloronicotinic acid, respectively, without need for purification of intermediates. Copyright
Quaternary Heterocyclylamino β-Lactams: A Generic Alternative to the Classical Acylamino Side Chain
Hannah, John,Johnson, Charles R.,Wagner, Arthur F.,Walton, Edward
, p. 457 - 469 (2007/10/02)
6β-penam-3-carboxylates and 7β-ceph-3-em-4-carboxylates have been found to be interesting new classes of antibacterial β-lactams, readily available by SN2 Ar coupling of fluoro-substituted quaternized pyridines and appropriate amino lactam carboxylic acids.Compared to penicillin G, the penam 12c exhibited a spectrum extended to Gram-negative species, such as Escherichia, Shigella, Klebsiella and Enterobacter, offset by a loss of potency against Gram-positive spacies.Excluding Pseudomonas, many examples of the cephems showed excellent activity against the above Gram-negative organisms, and in some cases, such as 15i, the spectrum included good performance against the staphylococci and streptococci.With Serratia and many Proteus species, there was an adverse inoculum and medium effect which was not observed in the good Gram-positive reach of the cephem series.
