80716-35-4Relevant academic research and scientific papers
The synthesis of wrightiadione via directed remote metalation
Thasana, Nopporm,Ruchirawat, Somsak
, p. 1037 - 1039 (2007/10/03)
The application of directed remote metalation (DreM) and electrophilic substitution is reported for the synthesis of wrightiadione using N,N-diethylcarboxamide as a directed metalation group (DMG) and electrophilic group. The lithiation of N,N-diethylisoflavone-2′-carboxamide with LDA gave a carbanion at C-2 which further cyclized to wrightiadione.
