80717-16-4Relevant academic research and scientific papers
Organocatalytic Regioselective Chlorosilylation of Oxirane Derivatives: Mild and Effective Insertion of Bulky Silyl Chloride by Using 4-Methoxypyridine N-Oxide
Yoshida, Keisuke,Suzuki, Hina,Inoue, Hiroki,Matsui, Kohei,Fujino, Yuta,Kanoko, Yohei,Itatsu, Yukihiro,Takao, Ken-Ichi
, p. 1886 - 1891 (2016)
The highly regioselective organocatalytic chlorosilylation of oxirane derivatives using bulky silyl reagents such as (tert-butyl)diphenylsilyl chloride (TBDPSCl) or triphenylsilyl chloride (Ph3SiCl) was developed. The reaction was effectively catalyzed with 4-methoxypyridine N-oxide in the presence of sodium sulfate (Na2SO4). Several silylated halohydrins were obtained with complete regioselectivity and the reaction was applied to the synthesis of carvedilol. (Figure presented.) .
NUCLEOPHILIC CATALYSIS IN THE INSERTION OF SILICON HALIDES INTO OXIRANES: A SYNTHESIS OF O-PROTECTED VICINAL HALOHYDRINS
Andrews, Glenn, C.,Crawford, Thomas C.,Contillo, Leonard G.
, p. 3803 - 3806 (2007/10/02)
Silicon halides in the presence of nucleophilic catalysts react with epoxides to form O-protected vicinal halohydrins with enhanched regioselectivity.
