807325-86-6Relevant articles and documents
Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration
Lunniss, Christopher J.,Cooper, Anthony W.J.,Eldred, Colin D.,Kranz, Michael,Lindvall, Mika,Lucas, Fiona S.,Neu, Margarete,Preston, Alex G.S.,Ranshaw, Lisa E.,Redgrave, Alison J.,Ed Robinson,Shipley, Tracy J.,Solanke, Yemisi E.,Somers, Don O.,Wiseman, Joanne O.
scheme or table, p. 1380 - 1385 (2009/10/02)
Crystallography-driven optimisation of a lead derived from similarity searching of the GSK compound collection resulted in the discovery of a series of quinoline derivatives that were highly potent and selective inhibitors of PDE4 with a good pharmacokine
