807329-97-1

Usage

Uses

Used in Organic Synthesis:
ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL& is used as a reagent for the regioselective functionalization of trisubstituted pyridines, which is important for the synthesis of various pharmaceutical and agrochemical compounds.
Used in Amination Reactions:
It is used as an electrophilic aminating agent for the preparation of amines and functionalization of cyclopentene derivatives. This is crucial for the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Used in Heterocyclic Compound Synthesis:
ISOPROPYLMAGNESIUM CHLORIDE LITHIUM CHL& is used in the preparation of 2,3-functionalized furans, benzofurans, and thiophenes. These heterocyclic compounds are important building blocks in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals.
Used in Benzylic Grignard Synthesis:
It is used in the synthesis of benzylic Grignards via sulfur-magnesium exchange. This is an important method for the preparation of various organic compounds, including pharmaceuticals and agrochemicals.

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 75-29-6 isopropyl chloride 
• 7439-95-4 magnesium 

Downstream Products

• 857934-96-4 3-allyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 1031850-02-8 (R)-(3-isopropyl-4,7,7-trimethylbicyclo[2.2.1]hept-2-en-2-yl)phenylmethanone 
• 86186-47-2 (2-isopropylcyclopent-1-en-1-yl)phenylmethanone 
• 1105707-41-2 2-(N-allyl-N-benzylamino)-N,3-dimethylbutanamide 
• 611-69-8 rac-2-methyl-1-phenylpropan-1-ol 
• 1155702-46-7 1-[3-(chloromethyl)phenyl]-2-methylpropan-1-one 
• 13828-31-4 m-menth-1-ene 

Relevant academic research and scientific papers

Regioselective Bromine/Magnesium Exchange for the Selective Functionalization of Polyhalogenated Arenes and Heterocycles

Using the bimetallic combination sBu2Mg?2 LiOR (R=2-ethylhexyl) in toluene enables efficient and regioselective Br/Mg exchanges with various dibromo-arenes and -heteroarenes under mild reaction conditions and provides bromo-substituted magnesiu

Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides

Magnesium organometallic reagents occupy a central position in organic synthesis. The freshness of these compounds is the key for achieving a high conversion and reproducible results. Common methods for the synthesis of Grignard reagents from metallic magnesium present safety issues and exhibit a batch-to-batch variability. Tubular reactors of solid reagents combined with solution-phase reagents enable the continuous-flow preparation of organomagnesium reagents. The use of stratified packed-bed columns of magnesium metal and lithium chloride for the synthesis of highly concentrated turbo Grignards is reported. A low-cost pod-style synthesizer prototype, which incorporates single-use prepacked perfluorinated cartridges and bags of reagents for the automated on-demand lab-scale synthesis of carbon, nitrogen, and oxygen turbo magnesium bases is presented. This concept will provide access to fresh organomagnesium reagents on a discovery scale and will do so independent from the operator’s experience in flow and/or organometallic chemistry.

Nitrile-substituted 2-(oxazolinyl)-phenols: Minimalistic excited-state intramolecular proton transfer (ESIPT)-based fluorophores

Herein, we present minimalistic single-benzene, excited-state intramolecular proton transfer (ESIPT)-based fluorophores as powerful solid-state emitters. The very simple synthesis gave access to all four regioisomers of nitrile-substituted 2-(oxazolinyl)-

Emission color-tunable oxazol(in)yl-substituted excited-state intramolecular proton transfer (ESIPT)-based luminophores

Oxazolinyl- and arylchalcogenazolyl-substituted hydroxyfluorenes exhibiting excited-state intramolecular proton transfer (ESIPT) are described as potent and highly modular luminophores. Emission color tuning was achieved by varying the π-expansion and the

Thiolation of Pyridine-2-sulfonamides using Magnesium Thiolates

The thiolation of pyridine-2-sulfonamides using magnesium thiolates is reported. The ortho-functionalizations of these sulfonamides using TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by electrophilic quenching produced a range of 3-functiona

Zincation and Magnesiation of Functionalized Silylated Cyanohydrins Using TMP-Bases

Polyfunctional silylated cyanohydrins are readily magnesiated or zincated with TMPMgCl·LiCl or TMP 2 Zn·2MgCl 2 ·2LiCl leading to the corresponding metallated derivatives. These Mg- or Zn-derivatives react with various electrophiles such as benzylic bromides, allylic bromides, acid chlorides, aldehydes, NCCO 2 Et, or MeSO 2 SMe. Subsequently, TBAF-deprotection provides the corresponding keto or 1,2-diketo derivatives.

NOVEL BRONCHODILATING DIAZAHETEROARYLS

The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.

HETEROCYCLIC ANTIVIRAL COMPOUNDS

Compounds of formula I, wherein R1, R2, R3, X1, X2 and Ar, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein A is A1, A2, A3 or A4 and R1, R2, R3, R4a, R4b, R5, R6, Ar, X1, X2, X4, X4 and X5 are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.

Heterocyclic reverse transcriptase inhibitors

The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where R1, R2 and R3, are as defined herein.