807352-36-9Relevant academic research and scientific papers
Synthesis of a new class of furan-fused tetracyclic compounds using o-quinodimethane chemistry and investigation of their antiviral activity
Matsuya, Yuji,Sasaki, Kazushige,Nagaoka, Mamiko,Kakuda, Hiroko,Toyooka, Naoki,Imanishi, Nobuko,Ochiai, Hiroshi,Nemoto, Hideo
, p. 7989 - 7993 (2004)
The synthesis and evaluation of antiviral activity of new furan-fused tetracyclic compounds are described. The syntheses were satisfactorily achieved on the basis of o-quinodimethane chemistry, using furan-containing benzocyclobutene derivatives as a substrate, in high generality and stereoselectivity. The various derivatives thus synthesized were examined on their inhibitory activity on virus growth using a hemagglutinin (HA) method, leading to a discovery of promising candidates for new antiviral drugs having high activity and good therapeutic index.
