807354-69-4Relevant academic research and scientific papers
Concise synthesis of quinazoline alkaloids, luotonins A and B, and rutaecarpine
Harayama, Takashi,Hori, Akihiro,Serban, Georgeta,Morikami, Yoshiaki,Matsumoto, Takuya,Abe, Hitoshi,Takeuchi, Yasuo
, p. 10645 - 10649 (2007/10/03)
The total synthesis of luotonin A was achieved in excellent yield by using a Pd-assisted biaryl coupling reaction of N-(bromoquinolinyl)methylquinazolinone with Cy3P and KOAc. The successive treatment of luotonin A with NBS and aq. AgNO3 gave luotonin B in good yield. Although the Pd-assisted coupling reaction of N-(2-bromoindolyl)ethylquinazolinone with Cy3P and KOAc yielded rutaecarpine in poor yield, N-acetate under the same reaction conditions yielded the desired rutaecarpine directly in excellent yield. Graphical Abstract.
