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SKF 83959 HYDROBROMIDE is a benzazepine compound that acts as a dopamine D1-like receptor partial agonist with varying Ki values for different dopamine receptors. It has the potential to act as an antagonist in vivo, offering anti-Parkinsonian effects and counteracting the behavioral effects of cocaine.

80751-85-5

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80751-85-5 Usage

Uses

Used in Pharmaceutical Industry:
SKF 83959 HYDROBROMIDE is used as a research compound for studying the role of dopamine receptors in various neurological and psychiatric disorders. Its agonist and antagonist properties make it a valuable tool in understanding the mechanisms of action and potential therapeutic applications in treating conditions such as Parkinson's disease and addiction.
Used in Neuroscience Research:
In the field of neuroscience, SKF 83959 HYDROBROMIDE is utilized as a selective ligand to investigate the function and regulation of dopamine D1-like receptors. This helps researchers gain insights into the complex interactions between these receptors and their role in cognitive, motor, and reward processes.
Used in Drug Development:
SKF 83959 HYDROBROMIDE serves as a lead compound in the development of novel therapeutic agents targeting dopamine D1-like receptors. Its unique pharmacological profile may contribute to the creation of new drugs for the treatment of neurological and psychiatric disorders, as well as for the management of drug addiction and abuse.

Biological Activity

Dopamine D 1 -like receptor partial agonist (K i values are 1.18, 7.56, 920 and 399 nM for rat D 1 , D 5 , D 2 and D 3 receptors respectively). May act as an antagonist in vivo , producing antiparkinsonian effects and antagonizing the behavioral effects of cocaine.

Check Digit Verification of cas no

The CAS Registry Mumber 80751-85-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,7,5 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 80751-85:
(7*8)+(6*0)+(5*7)+(4*5)+(3*1)+(2*8)+(1*5)=135
135 % 10 = 5
So 80751-85-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3

80751-85-5 Well-known Company Product Price

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  • Sigma

  • (S2816)  SKF-83959 hydrobromide  ≥98% (HPLC), solid

  • 80751-85-5

  • S2816-5MG

  • 2,347.02CNY

  • Detail
  • Sigma

  • (S2816)  SKF-83959 hydrobromide  ≥98% (HPLC), solid

  • 80751-85-5

  • S2816-25MG

  • 8,400.60CNY

  • Detail

80751-85-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol

1.2 Other means of identification

Product number -
Other names 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:80751-85-5 SDS

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