807626-26-2

Upstream product

• 108735-94-0 1-Ethyl 4-methyl 2-hydroxy 3-methylenebutanedioate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 807626-23-9 1-ethyl-4-methyl-2-tert-butyldimethylsilyloxy-3-methylenebutanedioate 

Downstream Products

• 807626-33-1 (3S,4R,1'S)-4-benzyloxymethyl-3-tert-butyldimethylsilyloxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 807626-34-2 (3R,4R,1'S)-4-benzyloxymethyl-3-hydroxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 807626-35-3 (3R,4R,1'S)-4-benzyloxymethyl-3-hydroxy-1-(1'-phenylethyl)pyrrolidine 
• 267421-93-2 (3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidine 
• 859214-17-8 (3S,4R,1'S)-4-benzoyloxymethyl-3-t-butyldimethylsilyloxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 859214-21-4 (3S,4S,1'S)-4-benzoyloxymethyl-3-t-butyldimethylsilyloxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 859214-19-0 (3S,4R,1'S)-4-benzoyloxymethyl-3-methanesulfonyloxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 859214-23-6 (3S,4S,1'S)-4-benzoyloxymethyl-3-methanesulfonyloxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 859214-22-5 (3S,4S,1'S)-4-benzoyloxymethyl-3-hydroxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 859214-18-9 (3S,4R,1'S)-4-benzoyloxymethyl-3-hydroxy-1-(1'-phenylethyl)pyrrolidin-2-one 
• 807626-37-5 (3S,4S,1'S)-3-tert-butyldimethylsilyloxy-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one 
• 807626-32-0 (3S,4R,1'S)-3-tert-butyldimethylsilyloxy-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

Chiral 3-hydroxypyrrolidin-2-ones from a Baylis-Hillman adduct: Convergent, stereoselective synthesis of a glycosidase inhibitor

The O-silyl derivative 4b, prepared starting from the Baylis-Hillman adduct 4a, underwent cyclization on treatment with (S)-phenylethylamine, to give to an equimolar mixture of the 4,5-cis-disubstituted pyrrolidin-2-ones 9 and 10, exclusively, which after

NUCLEOSIDE ANALOGUES FOR THE TREATMENT OF VIRAL INFECTIONS AND METHODS FOR PREPARING THEM

New pyrrolidine derivatives are disclosed having formula (I) wherein R1 and R2 are protecting groups independently selected from R-C(=O), wherein R is straight or branched C1-C15 alkyl, C6-C15 aryl, substituted C5-C15 aryl including from (1) to (5) heteroatoms and R3 is a nucleobase selected from thymine I, cytosine II, adenine III, guanine IV, uracile V, xanthine VI and hypoxanthine VII, a derivative of said nucleobases I- VII protected at the reactive functionalities NH2 or imidic NH, a deazacarbocyclic derivative of said nucleobases I-VII optionally protected at the reactive functionality NH2. These pyrrolidine derivatives are nucleoside isosteres and can be employed for the synthesis of DNA chimeras or as termination sequences for diagnostic and therapeutic applications. Also disclosed are novel intermediates useful for the preparation of the aforementioned pyrrolidine derivatives, as well as to methods for preparing both the intermediates and the final pyrrolidine derivatives.