80775-79-7

Upstream product

• 126443-11-6 4'-fluoro-4-methoxy-trans-chalcone 
• 1774-47-6 trimethylsulfoxonium iodide 
• 345308-47-6 3-(4-Fluoro-benzoyl)-4-(4-methoxy-phenyl)-dihydro-furan-2-one 
• 479582-18-8 β-(4-methoxyphenyl)-γ-butyrolactone 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 80775-64-0 4-chloro-1-(4-fluorophenyl)-3-(4-methoxyphenyl)-1-butanone 

Relevant academic research and scientific papers

Hantzsch Ester-Mediated Photochemical Transformations in the Ketone Series: Remote C(sp3)-H Arylation and Cyclopentene Synthesis through Strain Release

A metal-free Hantzsch ester-mediated synthesis of cyclopentenylketones as well as O-hetarylketones starting from ketocyclopropanes under eco-friendly conditions was developed. The versatility of the developed conditions is shown by reacting ketocyclopropanes in both a formal [3 + 2] cycloaddition with terminal alkynes (further investigated using theoretical calculations) and a radical C-C-coupling with cyanopyridines. The newly developed methodologies were later on utilized as a downstream reaction for photogenerated cyclopropanes combining UV and visible light photochemistry. Following this procedure, a UV-driven Norrish-Yang-type reaction induces the ring strain of the intermediates, which serves as activation energy for the subsequent ring transformation.