80776-93-8 Usage
Chemical class
Quinazolinone derivative
Explanation
The compound belongs to a class of organic compounds derived from quinazoline, which is a tricyclic fused indole-pyridine ring system.
Explanation
Antineoplastic refers to the ability to inhibit or prevent the growth and spread of tumors, making it a potential candidate for cancer treatment.
Explanation
The compound is artificially synthesized, not found naturally occurring.
Explanation
The core structure of the compound is a pyridoquinazolinone, which is a fused ring system of indole and pyridine. It has four methoxy groups attached, which may contribute to its biological activity.
Explanation
Research has shown that the compound may slow down or prevent the growth and spread of cancer cells, making it a promising candidate for further development as a cancer therapy.
Explanation
The presence of tetrahydro (six-membered carbon rings) and trimethoxy (three methoxy groups) in the molecule may contribute to its stability, making it more resistant to degradation in biological systems.
Explanation
The tetrahydro and trimethoxy groups may also enhance the compound's bioavailability, allowing it to be more effectively absorbed and utilized by the body.
Explanation
Due to its potential antineoplastic activity and inhibitory effects on tumor growth, the compound is considered a promising candidate for further research and development as a cancer treatment option.
Potential activity
Antineoplastic
Synthetic compound
Yes
Molecular structure
Pyridoquinazolinone core with four methoxy groups
Biological activity
Inhibitory effects on tumor growth and progression
Stability
Enhanced by tetrahydro and trimethoxy groups
Bioavailability
Potentially improved by tetrahydro and trimethoxy groups
Further development
Promising candidate for cancer therapy
Check Digit Verification of cas no
The CAS Registry Mumber 80776-93-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,7,7 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 80776-93:
(7*8)+(6*0)+(5*7)+(4*7)+(3*6)+(2*9)+(1*3)=158
158 % 10 = 8
So 80776-93-8 is a valid CAS Registry Number.
80776-93-8Relevant articles and documents
Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors
Liu, Ji-Feng,Wilson, Christopher J.,Ye, Ping,Sprague, Kevin,Sargent, Katie,Si, Ying,Beletsky, Galina,Yohannes, Daniel,Ng, Shi-Chung
, p. 686 - 690 (2006)
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
