80795-53-5Relevant articles and documents
HCV POLYMERASE INHIBITORS
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, (2013/06/27)
The invention provides compounds of the formula:(I) which are of use in the treatment or prophylaxis of hepatitis C virus infection, and related aspects.
Uracyl Spirooxetane Nucleoside Phosphoramidates
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, (2013/09/12)
This invention relates to a stereochemically pure uracyl spirooxetane nucleoside phosphoramidate which inhibits the hepatitis C virus (HCV).
Synthesis and properties of triplex-forming oligonucleotides containing 2′-O-(2-methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine
Lou, Chenguang,Xiao, Qiang,Brennan, Lavinia,Light, Mark E,Vergara-Irigaray, Nuria,Atkinson, Elizabeth M.,Holden-Dye, Lindy M.,Fox, Keith R.,Brown, Tom
experimental part, p. 6389 - 6397 (2010/10/05)
2′-O-(2-Methoxyethyl)-5-(3-aminoprop-1-ynyl)-uridine phosphoramidite (MEPU) has been synthesized from d-ribose and 5-iodouracil and incorporated into triplex-forming oligonucleotides (TFOs) by automated solid-phase oligonucleotide synthesis. The TFOs gave very high triplex stability with their target duplexes as measured by ultraviolet/fluorescence melting and DNase I footprinting. The incorporation of MEPU into TFOs renders them resistant to degradation by serum nucleases.