80798-51-2

Basic information

• Product Name: 6-amino-1-ethyl-5-nitrosopyrimidine-2,4(1H,3H)-dione
• CAS NO: 80798-51-2
• Molecular Formula: C₆H₈N₄O₃
• Molecular Weight: 184.1527
• Mol File: 80798-51-2.mol
• Article Data: 12

Chemical Properties

• Density: 1.69g/cm³
• Refractive Index: 1.7
• CAS DataBase Reference: 6-amino-1-ethyl-5-nitrosopyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-1-ethyl-5-nitrosopyrimidine-2,4(1H,3H)-dione(80798-51-2)
• EPA Substance Registry System: 6-amino-1-ethyl-5-nitrosopyrimidine-2,4(1H,3H)-dione(80798-51-2)

Safety Data

• Hazardous Substances Data: 80798-51-2(Hazardous Substances Data)

Upstream product

• 41862-09-3 1-ethyl-6-aminouracil 
• 41078-06-2 2-cyano-N-(ethylcarbamoyl)acetamide 

Downstream Products

• 139927-84-7 7-benzyl-3-ethylxanthine 
• 41078-01-7 3-Ethylxanthine 

Relevant articles and documents

SUBSTITUTED XANTHINE DERIVATIVES

The present invention relates to compounds of formula (I) a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment of conditions having an association with TRPC5 containing ion ch

NOVEL SUBSTITUTED XANTHINE DERIVATIVES

The present invention relates to substituted xanthine derivatives, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment of conditions having an association with TRPC5 containing ion channels.

Imidazopyridine- and purine-thioacetamide derivatives: Potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels. To study the (patho)physiological roles of NPP1 potent and selective inhibitors with drug-like properties are required. Therefore, a compound library was screened for NPP1 inhibitors using a colorimetric assay with p-nitrophenyl 5′-thymidine monophosphate (p-Nph-5′-TMP) as an artificial substrate. This led to the discovery of 2-(3H-imidazo[4,5-b]pyridin-2-ylthio)-N-(3,4-dimethoxyphenyl)acetamide (5a) as a hit compound with a Ki value of 217 nM. Subsequent structure-activity relationship studies led to the development of purine and imidazo[4,5-b]pyridine analogues with high inhibitory potency (Ki values of 5.00 nM and 29.6 nM, respectively) when assayed with p-Nph-5′-TMP as a substrate. Surprisingly, the compounds were significantly less potent when tested versus ATP as a substrate, with Ki values in the low micromolar range. A prototypic inhibitor was investigated for its mechanism of inhibition and found to be competitive versus both substrates.