80809-81-0

Hazards Identification

Pictogram(s):

Signal:

Warning

GHS Hazard Statements:

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statement Codes:

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories:

Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)

Usage

Uses

Used in Pharmaceutical Industry:
AA-861 is used as an inhibitor for 5-lipoxygenase, an enzyme involved in the production of inflammatory mediators. This makes it a potential candidate for the development of anti-inflammatory drugs.
Used in Cancer Research:
AA-861 is used as an inhibitor of colon cancer cells invasion and metastasis in humans. Its ability to suppress the invasive and metastatic properties of cancer cells makes it a promising agent for cancer treatment and prevention.

InChI:InChI=1/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h22H,5,7-10,12,14-15H2,1-3H3

Upstream product

• 80810-05-5 1-(12-hydroxydodeca-5,10-diynyl)-2,5-dimethoxy-3,4,6-trimethylbenzene 
• 62992-46-5 1-(tetrahydropyranyloxy)-4-pentyn 
• 32080-47-0 8-(tetrahydropyran-2-yloxy)octa-1,6-diyne 
• 80810-61-3 4-(2,5-dimethoxy-3,4,6-trimethylphenyl)butan-1-ol 
• 80810-26-0 2,3,5-trimethyl-1,4-dimethoxy-6-(4-iodobutyl)benzene 
• 80810-60-2 1,4-dimethoxy-2,3,5-trimethyl-6-(tetrahydrofur-2-yl)benzene 
• 80810-32-8 1-(9-Iodo-non-5-ynyl)-2,5-dimethoxy-3,4,6-trimethyl-benzene 
• 80810-04-4 9-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-non-4-yn-1-ol 
• 118647-24-8 2-[12-(2,5-Dimethoxy-3,4,6-trimethyl-phenyl)-dodeca-2,7-diynyloxy]-tetrahydro-pyran 

Relevant academic research and scientific papers

Quinones. Part 3. Synthesis of Quinone Derivatives having Ethylenic and Acetylenic Bonds: Specific Inhibitors of the Formation of Leukotrienes and 5-Hydroxyicosa-6,8,11,14-tetraenoic Acid (5-HETE)

A new series of quinone derivatives with alkenyl and alkynyl groups in the side chain has been synthesised.A ready and novel synthetic method for the preparation of quinone derivatives via application of a 4-hydroxybutylation reaction discovered in our laboratory has been developed.Oxidative demethylation of the hydroquinone dimethyl ethers (5), (9), and (10) with cerium(IV) ammonium nitrate selectively leads to the formation of the desired quinone derivatives (11)-(13) in good yield, in spite of the presence of double or triple bonds, hydroxy groups in the side chains, and/or four methoxy groups on the same phenyl ring.Inhibitory effects of these quinone derivatives on the formation of leukotrienes 4, LTD4, LTB4, and (5S,12S)- and (5S,12R)-6-trans-LTB4> and 5-hydroxyicosa-6,8,11,14-tetraenoic acid (5-HETE) in rat basophilic leukaemia (RBL-1) cells were evaluated.It was found that quinone derivatives such as 2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone (AA-861) (12d) proved to be potent and specific inhibitors of leukotrienes and 5-HETE formation from arachidonic acid.