80810-53-3

Basic information

• Product Name: 4-methyl-2-(tetrahydrofuran-2-yl)phenol
• CAS NO: 80810-53-3
• Molecular Weight: 178.231
• Mol File: 80810-53-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-2-(tetrahydrofuran-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-2-(tetrahydrofuran-2-yl)phenol(80810-53-3)
• EPA Substance Registry System: 4-methyl-2-(tetrahydrofuran-2-yl)phenol(80810-53-3)

Safety Data

• Hazardous Substances Data: 80810-53-3(Hazardous Substances Data)

Upstream product

• 13481-09-9 2-(4-methylphenoxy)tetrahydro-2H-pyran 

Relevant articles and documents

The Thermal ortho-Substitution of Phenols by Vinyl Ethers

Pyrolysis of a mixture of phenol and 3,4-dihydro-2H-pyran (6) at 150-180 deg C resulted in the formation of 2-(tetrahydro-2H-pyran-2-yl)phenol (3a) in moderate yield.This selective ortho-substitution reaction has been investigated for a range of phenols and a number of vinyl ethers.While it was found to be a fairly general reaction for phenols, only with the vinyl ether (6) and 2,3-dihydrofuran (28a) was the reaction found to be regioselective.Aluminium phenylate strongly catalyses the reaction of phenol with (6), which proceeded under these conditions at room temperature.An ene-type mechanism is proposed for the reaction.