808102-09-2Relevant articles and documents
Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles
Le Bourdonnec, Bertrand,Barker, William M.,Belanger, Serge,Wiant, Daniel D.,Conway-James, Nathalie C.,Cassel, Joel A.,O'Neill, Timothy J.,Little, Patrick J.,DeHaven, Robert N.,DeHaven-Hudkins, Diane L.,Dolle, Roland E.
, p. 2006 - 2012 (2008)
A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, μ opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective μ opioid receptor ant