808109-47-9

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 188783-40-6 α/β‐L‐glucopyranosyl‐1,2,3,4,5‐pentaacetate 
• 808109-86-6 2,2-Dimethyl-propionic acid (2S,3S,4R,5R,6S)-6-allyl-5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-ylmethyl ester 
• 808109-75-3 Acetic acid (2S,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-allyl-tetrahydro-pyran-4-yl ester 
• 808109-45-7 (4aS,6S,7R,8S,8aS)-6-Allyl-8-methoxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 808109-38-8 (4aS,6S,7S,8S,8aR)-6-Allyl-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol 
• 477845-03-7 (2S,3S,4S,5R,6S)-2-Allyl-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol 

Downstream Products

• 808109-88-8 2-[(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-ethanol 
• 808109-48-0 [(2S,3S,4R,5R,6S)-5-(tert-Butyl-dimethyl-silanyloxy)-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methoxy-3-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yl]-acetaldehyde 
• 808109-87-7 (2S,3R,4R,5S,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-methoxy-5-(4-methoxy-benzyloxy)-6-vinyl-tetrahydro-pyran 

Relevant academic research and scientific papers

Structurally simplified macrolactone analogues of halichondrin B

Structurally simplified macrolactone analogues of halichondrin B (e.g., 47, IC50 = 0.67 nM) were identified that retain the potent cell growth inhibitory activity of the natural product in vitro. A structurally simplified macrolactone analogue of halichondrin B was identified that retains the potent cell growth inhibitory activity of the natural product in vitro.