808134-43-2Relevant academic research and scientific papers
Facile preparation of an orthogonally protected, pH-sensitive, bioconjugate linker for therapeutic applications
Fletcher, Steven,Jorgensen, Michael R.,Miller, Andrew D.
, p. 4245 - 4248 (2007/10/03)
(Chemical Equation Presented) We describe the facile, three-step synthesis of an orthogonally protected, pH-sensitive linker (8), based on maleic acid, and report its application to the preparation of a pH-sensitive phospholipid (20) for potential use in drug and gene delivery. In addition, we highlight the benefits of our linker over the use of the commercially available cis-aconitic anhydride (4).
