808146-78-3Relevant academic research and scientific papers
Triphosgene-amine base promoted chlorination of unactivated aliphatic alcohols
Villalpando, Andres,Ayala, Caitlan E.,Watson, Christopher B.,Kartika, Rendy
, p. 3989 - 3996 (2013)
Unactivated α-branched primary and secondary aliphatic alcohols have been successfully transformed into their corresponding alkyl chlorides in high yields upon treatment with a mixture of triphosgene and pyridine in dichloromethane at reflux. These mild chlorination conditions are high yielding, stereospecific, and well tolerated by numerous sensitive functionalities. Furthermore, no nuisance waste products are generated in the course of the reactions.
