80816-94-0Relevant academic research and scientific papers
Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block
Grove, Simon J.A.,Kaur, Jasmit,Muir, Alan W.,Pow, Eleanor,Tarver, Gary J.,Zhang, Ming-Qiang
, p. 193 - 196 (2007/10/03)
A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Several compounds, for example 2-hydroxy- and 2-methoxy-N,N-dimethyl-N-allylanilinium bromide (3 and 6) showed comparable reversal potencies to edrophonium and clean in vivo cardiovascular profiles.
Base Catalysed Rearrangements involving Ylide Intermediates. Part 13. Further Rearrangements of 2-Oxidoanilinium Ylides
Ollis, W. David,Somanathan, Ratnasamy,Sutherland, Ian O.
, p. 2930 - 2942 (2007/10/02)
The 2-oxidoanilinium ylides (7) rearrange on heating to give the ethers (10) together with the dienones (8) and the phenols (11) for cases where the aromatic ring has a 5-alkyl substituent or a mixture of the dienones (8) and (12) for cases where the aromatic ring is 3,5-disubstituted.A study of the deuteriated ylides (25) shows that these reactions involve competing concerted and radical-pair processes.The base-catalysed rearrangements of the 2-hydroxy-N-pentadienylanilinium salts (33) give the ethers (34) and the phenols (35): these products result from competing concerted and rearrangements of the ylides (36) corresponding to the salts (33).
