808170-07-2Relevant academic research and scientific papers
Non-thiol farnesyltransferase inhibitors: N-(4-acylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.
Kettler, Katja,Sakowski, Jacek,Silber, Katrin,Sattler, Isabel,Klebe, Gerhard,Schlitzer, Martin
, p. 1521 - 1530 (2007/10/03)
We have designed the nitrophenylfurylacryl-substituted benzophenone 4f as a non-thiol farnesyltransferase inhibitor utilizing a novel aryl binding site of farnesyltransferase. Variation of the 2-acylamino substituent at the benzophenone core structure of
