808186-32-5

Basic information

• Product Name: (3S,7aS)-7a-(2,4-Difluoro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
• Synonyms: (3S,7aS)-7a-(2,4-Difluoro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
• CAS NO: 808186-32-5
• Molecular Weight: 315.319
• Mol File: 808186-32-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,7aS)-7a-(2,4-Difluoro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,7aS)-7a-(2,4-Difluoro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one(808186-32-5)
• EPA Substance Registry System: (3S,7aS)-7a-(2,4-Difluoro-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one(808186-32-5)

Safety Data

• Hazardous Substances Data: 808186-32-5(Hazardous Substances Data)

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 20989-17-7 (2S)-2-phenylglycinol 
• 110931-77-6 4-(2,4-difluorophenyl)-4-oxobutanoic acid 

Downstream Products

• 808189-33-5 2-[1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-N-(3-chloro-2-methyl-benzyl)-acetamide 
• 808189-08-4 [(3R,5R)-3-[(3-Chloro-2-methyl-benzylcarbamoyl)-methyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-1-yl]-acetic acid 
• 808189-24-4 [(3R,5R)-1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-2-oxo-pyrrolidin-3-yl]-acetic acid 
• 808189-18-6 (3S,5R)-3-Allyl-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-pyrrolidin-2-one 
• 808189-11-9 1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-(2,4-difluoro-phenyl)-pyrrolidin-2-one 
• 808186-50-7 (R)-1-((S)-2-Chloro-1-phenyl-ethyl)-5-(2,4-difluoro-phenyl)-pyrrolidin-2-one 
• 808186-56-3 (R)-5-(2,4-Difluoro-phenyl)-1-(1-phenyl-vinyl)-pyrrolidin-2-one 
• 808186-62-1 (R)-5-(2,4-Difluoro-phenyl)-pyrrolidin-2-one 
• 808186-44-9 (R)-5-(2,4-Difluoro-phenyl)-1-((S)-2-hydroxy-1-phenyl-ethyl)-pyrrolidin-2-one 

Relevant articles and documents

Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists

A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease. A series of racemic and chiral, nonracemic lactams that display high binding affinities, functional chemotaxis antagonism, and selectivity toward CCR4 are described. Compound 41, which provides reasonably high blood levels in mice when dosed intraperitoneally, was identified as a useful pharmacological tool to explore the role of CCR4 antagonism in animal models of allergic disease.