808196-22-7Relevant academic research and scientific papers
POLYPHENOL COMPOUNDS FOR INHIBITING PROTEASOME AND USES THEREOF
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Page/Page column 16; 19, (2011/06/28)
Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for inhibiting proteasomal activity and for treating cancer is also provided.
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs
Huo, Congde,Yang, Huanjie,Cui, Qiuzhi Cindy,Dou, Q. Ping,Chan, Tak Hang
experimental part, p. 1252 - 1258 (2010/04/26)
A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT.
