808196-28-3

Upstream product

• 808196-27-2 isoquinoline-5-sulfonic acid 2,6-dibromo-4-[2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-oxo-3-(4-o-tolyl-piperazin-1-yl)-propyl]-phenyl ester 
• 455-88-9 5-nitro-2-fluorotoluene 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 361345-36-0 tert-butyl 4-(2-methyl-4-nitrophenyl)piperazine-1-carboxylate 
• 361345-37-1 1-(t-butoxycarbonyl)-4-(4-amino-3-methylbenzene)sulphonylpiperazinide 
• 540-80-7 tert.-butylnitrite 
• 75-11-6 diiodomethane 
• 39512-51-1 1-(o-toluyl)piperazine 

Downstream Products

• 808196-30-7 {1-(4-hydroxy-benzyl)-2-[4-(4-iodo-2-methyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-methyl-carbamic acid tert-butyl ester 
• 808196-31-8 Isoquinoline-5-sulfonic acid 4-{(S)-3-[4-(4-iodo-2-methyl-phenyl)-piperazin-1-yl]-2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-oxo-propyl}-phenyl ester 

Relevant academic research and scientific papers

Thiazolidine derivatives or salts thereof as an active ingredient an inhibitor Pim

PROBLEM TO BE SOLVED: To provide compounds which have excellent Pim inhibitory action and are useful as pharmaceuticals.SOLUTION: A compound is a thiazolidine derivative represented by the general formula (1) in the figure, or a salt thereof. (In the formula, X represents O or S; Rrepresents a hydrogen atom or a Calkyl group; Z, Z, Z, Z, Zand Zeach independently represent CH or N; Y represents an optionally substituted, divalent Caromatic hydrocarbon group or the like; Am represents a disubstituted amino group, or an optionally substituted, nitrogen-containing saturated heterocyclic group; and Rand Reach independently represent a hydrogen atom, a halogen atom, an alkyl group or the like.)

Synthesis, radiolabeling, and preliminary biological evaluation of [ 3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl] -4-(o-tolyl)-piperazine, a potent antagonist radioligand for the P2X7 receptor

The design, synthesis, and preliminary biological evaluation of the first potent radioligand antagonist for the P2X7 receptor, named [ 3H]-1-[(S)-N,O-bis-(isoquinolinesulfonyl)-N-methyl-tyrosyl] -4-(o-tolyl)-piperazine (compound 13),