80825-06-5Relevant academic research and scientific papers
Discovery of N-Aroyl Diketone/Triketone Derivatives as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibiting-Based Herbicides
Fu, Ying,Zhang, Dong,Zhang, Shuai-Qi,Liu, Yong-Xuan,Guo, You-Yuan,Wang, Meng-Xia,Gao, Shuang,Zhao, Li-Xia,Ye, Fei
, (2019)
4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an important target site for discovering new bleaching herbicides. To explore novel HPPD inhibitors with excellent herbicidal activity, a series of novel N-aroyl diketone/triketone derivatives were rationally designed by splicing active groups and bioisosterism. Bioassays revealed that most of these derivatives displayed preferable herbicidal activity against Echinochloa crus-galli (EC) at 0.045 mmol/m2 and Abutilon juncea (AJ) at 0.090 mmol/m2. In particular, compound I-f was more potent compared to the commercialized compound mesotrione. Molecular docking indicated that the corresponding active molecules of target compounds and mesotrione shared similar interplay with surrounding residues, which led to a perfect interaction with the active site of Arabidopsis thaliana HPPD.
REAGENTS AND SYNTHETIC METHODS. 29. N-ACYLPHTHALIMIDES FROM CARBOXYLIC ACIDS AND PHOSPHOROUS REAGENTS UNDER PHASE TRANSFER CONDITIONS
Lago, J. M.,Palomo, C.
, p. 653 - 658 (2007/10/02)
N-acylphthalimides are obtained from carboxylic acids and potassium phthalimide by means of phenyl dichlorophosphoridate or diphenylphosphorophthalimide under phase transfer conditions.
