80835-30-9

Usage

Uses

Used in Pharmaceutical Development:
1-(4-(methylthio)phenyl)piperazine is used as a building block in the synthesis of pharmaceuticals and biologically active compounds, particularly for the development of potential drugs targeting psychiatric disorders and neurological conditions. Its structural features make it a versatile component in the creation of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(4-(methylthio)phenyl)piperazine is used as a key component in the design and synthesis of new drugs. Its ability to interact with various biological targets, such as dopamine and serotonin receptors in the brain, makes it an important candidate for the development of antipsychotic and neuroprotective agents.
Used in Neuropharmacology Research:
1-(4-(methylthio)phenyl)piperazine is used as a research tool in neuropharmacology to study the effects of compounds on dopamine and serotonin receptors. Understanding these interactions can lead to the development of more effective treatments for neurological and psychiatric conditions.

Upstream product

• 909418-89-9 tert-butyl 4-(4-(methylthio)phenyl)piperazine-1-carboxylate 
• 110-85-0 piperazine 
• 104-95-0 (4-bromophenyl)thioanisole 

Relevant academic research and scientific papers

Nickel-Catalyzed Cyanation of Aryl Thioethers

A nickel-catalyzed cyanation of aryl thioethers using Zn(CN)2 as a cyanide source has been developed to access functionalized aryl nitriles. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) in combination with the base KOAc (potassium acetate) is essential for achieving this transformation efficiently. This reaction involves both a C-S bond activation and a C-C bond formation. The scalability, low catalyst and reagents loadings, and high functional group tolerance have enabled both late-stage derivatization and polymer recycling, demonstrating the reaction's utility across organic chemistry.

ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

PIPERAZINE DERIVATIVES AS GLYT1 INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

Synthesis of potent and selective dopamine D4 antagonists as candidate radioligands

A series of dopamine D4 antagonists was synthesized and evaluated as potential candidates for development as positron emission tomography (PET) radioligands. All new compounds display high affinity and selectivity for the D4 receptors and compounds 5b, 5d, and 5e were identified as candidates for radioligand development.