80841-48-1Relevant academic research and scientific papers
Anticancer anilinoacridines. A process synthesis of the disubstituted amsacrine analog CI-921
Brennan,Colbry,Leeds,Leja,Priebe,Reily,Showalter,Uhlendorf,Atwell,Denny
, p. 1469 - 1476 (2007/10/02)
An improved process for the synthesis of bulk quantities of the clinical amsacrine analog CI-921 is reported. Described also are detailed analytical and spectroscopic data for this agent.
Potential antitumor agents. 40. Orally active 4,5-disubstituted derivatives of amsacrine
Denny,Atwell,Baguley
, p. 363 - 367 (2007/10/02)
The DNA-intercalating agent amsacrine is an effective drug for the treatment of human leukemias and lymphomas but has minimal solid tumor activity. As a first step in identifying analogues with a wider spectrum of activity, a comparison was made of the in
