80844-55-9Relevant academic research and scientific papers
Nondepressant β-adrenergic blocking agents. I Substituted 3-amino-1-(5, 6, 7, 8-tetrahydro-1-naphthoxy)-2-propanols
Condon,Cimarusti,Fox,Narayanan,Reid,Sundeen,Hauck
, p. 913 - 922 (2007/10/06)
A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for β-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols 12-15 were found to retain the β-blocking potency of propranolol but to lack its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical evaluation as a potential antianginal, antiarrhythmic, and antihypertensive agent.
