80854-14-4

Basic information

• Product Name: 2-(4-chlorophenyl)-2-methylpropanol
• Synonyms: 2-(4-Chlrophenyl)-2-methylpropanol
• CAS NO: 80854-14-4
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.6626
• Mol File: 80854-14-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 50 °C
• Boiling Point: 262.2 °C at 760 mmHg
• Flash Point: 112.4 °C
• Appearance: /
• Density: 1.115 g/cm³
• Vapor Pressure: 0.00559mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.74±0.10(Predicted)
• CAS DataBase Reference: 2-(4-chlorophenyl)-2-methylpropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-2-methylpropanol(80854-14-4)
• EPA Substance Registry System: 2-(4-chlorophenyl)-2-methylpropanol(80854-14-4)

Safety Data

• Hazardous Substances Data: 80854-14-4(Hazardous Substances Data)

Usage

General Description

The chemical 2-(4-chlorophenyl)-2-methylpropanol, also known as chlorphenesin, is a synthetic compound with antimicrobial and antifungal properties. It is commonly used as a preservative in various personal care and cosmetic products, including lotions, creams, and sunscreen. Chlorphenesin has also been found to have muscle-relaxing and anti-aging properties, making it an ingredient in some anti-wrinkle and anti-aging creams. While generally considered safe for use in topical products, it is important to follow recommended usage guidelines to minimize the risk of irritation or allergic reactions.

InChI:InChI=1/C10H13ClO/c1-10(2,7-12)8-3-5-9(11)6-4-8/h3-6,12H,7H2,1-2H3

Upstream product

• 57225-86-2 methyl 2-(4-chlorophenyl)-2-methylpropanoate 
• 13099-56-4 2-(4-chlorophenyl)-2-methyl-1-chloropropane 
• 6258-30-6 2-(4-chlorophenyl)-2-methylpropanoic acid 

Downstream Products

• 20401-29-0 α,α-dimethyl-(4-chlorophenyl)acetaldehyde 
• 83492-83-5 3-(4-bromophenoxy)-4-fluorobenzyl 2-(4-chlorophenyl)-2-methylpropyl ether 
• 80843-71-6 3-(4-methylphenoxy)benzyl 2-(4-chlorophenyl)-2-methylpropyl ether 
• 80844-07-1 etofenprox 
• 80854-21-3 3-phenoxybenzyl 2-(4-hydroxyphenyl)-2-methylpropyl ether 
• 853680-37-2 (S)-2-amino-3-(4-chlorophenyl)-3-methyl-butyric acid hydrochloride 
• 853680-38-3 (S)-2-tert-butoxycarbonylamino-3-(4-chlorophenyl)-3-methyl-butyric acid 
• 853680-36-1 (R)-4-methylbenzenesulfinic acid[2-(4-chlorophenyl)-2-methylpropylidene]-amide 

Relevant articles and documents

Synthesis and stereostructure-activity relationship of novel pyrethroids possessing two asymmetric centers on a cyclopropane ring

2-Methylcyclopropane pyrethroid insecticides bearing chiral cyanohydrin esters or chiral ethers and two asymmetric centers on the cyclopropane ring, were synthesized. These compounds were designed using a “reverse connection approach” between the isopropyl group in Fenvalerate, and between two dimethyl groups in an Etofenprox analogue (the methyl, ethyl form), respectively. These syntheses were achieved by accessible ring opening reactions of commercially available (±)-, (R)-, and (S)-propylene oxides using 4-chlorobenzyl cyanide anion as the crucial step, giving good overall yield of the product with >98% ee. The insecticidal activity against the common mosquito (Culex pipiens pallens) was assessed for pairs of achiral diastereomeric (1R*,2S*)-, (1R*,2R*)-cyanohydrin esters, and (1R*,2S*)-, (1R*,2R*)-ethers; only the (1R*,2R*)-ether was significantly effective. For the enantiomeric (1S,2S)-ether and (1R,2R)-ether, the activity was clearly centered on the (1R,2R)-ether. The present stereostructure?activity relationship revealed that (i) cyanohydrin esters derived from fenvalerate were unexpectedly inactive, whereas ethers derived from etofenprox were active, and (ii) apparent chiral discrimination between the (1S,2S)-ether and the (1R,2R)-ether was observed. During the present synthetic study, we performed alternative convergent syntheses of Etofenprox and novel 4-EtO-type (1S,2S)- and (1R,2R)-pyrethroids from the corresponding parent 4-Cl-type pyrethroids, by utilizing a recently-developed hydroxylation cross-coupling reaction.

AKT PROTEIN KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

2-aryl-ethyl ether derivatives and insecticidal and acaricidal agents containing said derivatives

The present invention relates to 2-arylethyl ether or thioether derivatives represented by the following general formula [I]: STR1 wherein Ar stands for an aryl group, R1 stands for straight or branched chain alkyl group of 1 to 6 carbons, R2 stands for a hydrogen atom, or a methyl or ethyl group, R3 stands for a halogen atom, or a methyl or methoxyl group, R4 stands for a hydrogen or halogen atom, or a lower alkyl or lower alkoxy group, and n is an integer of 1 or 2 with the proviso that when n is 2, the groups R4 may be the same or different, and Y stands for an oxygen or sulfur atom, and also to processes for the preparation of these ethers or thioethers and a use of these ethers or thioethers. These compounds of the present invention have excellent insecticidal and acaricidal activities while the toxicity of these compounds are very low.