80859-08-1

Usage

Uses

Used in Pharmaceutical Industry:
6,7-Dimethyl-4-chromanone is used as a key intermediate in the synthesis of various pharmaceuticals for its potential pharmacological activities.
Used in Fragrance Industry:
6,7-Dimethyl-4-chromanone is used as a building block in the creation of fragrances due to its unique structure and properties.
Used in Chemical Industry:
6,7-Dimethyl-4-chromanone is used in the synthesis of other fine chemicals, contributing to the development of new compounds and products.

Upstream product

• 25173-39-1 β-(3,4-dimethylphenoxy)propionic acid 
• 107-13-1 acrylonitrile 
• 105-67-9 2,4-Xylenol 
• 91132-30-8 3-(3,4-dimethyl-phenoxy)-propionitrile 
• 95-65-8 3,4-Dimethylphenol 

Downstream Products

• 65249-14-1 6,7-dimethyl-2-phenylchroman-4-one 

Relevant academic research and scientific papers

Synthesis and anti-inflammatory activity of 2-oxo-2H-chromenyl and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates

Cycloaddition reaction of 4-chloro-2-oxo-2H-chromene-3-carbaldehydes (3a-g) and 4-chloro-2H-chromene-3-carbaldehydes (7a-h) with activated alkynes (4a-b) provided the 2-oxo-2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (5a-n) and 2H-chromenyl-5-oxo-2,5-dihydrofuran-3-carboxylates (8a-p). All the prepared compounds were screened for anti-inflammatory activity. In vitro anti-inflammatory activity data demonstrated that the compounds 5g, 5i, 5k-l and 8f are effective among the tested compounds against TNF-α (1.108 ± 0.002, 0.423 ± 0.022, 0.047 ± 0.001, 0.070 ± 0.002 and 0.142 ± 0.001 μM) in comparison with standard compound Prednisolone (0.033 ± 0.002 μM). Based on in vitro results, three compounds (5i, 5k and 8f) have been selected for in vivo experiments and these compounds are identified as better compounds with respect to anti-inflammatory activity in LPS induced mice model. Compound 5i was identified as potent and showed significant reduction in TNF-α and IL-6.

Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids

A total of 47 flavanones were expediently synthesized via one-pot β-arylation of chromanones, a class of simple ketones possessing chemically unactivated β sites, with arylboronic acids via tandem palladium(II) catalysis. This reaction provides a novel route to various flavanones, including natural products such as naringenin trimethyl ether, in yields up to 92percent.

A New Class of Antiarrhythmic Agents: Mannich Bases of 3,4-Dihydro-1-benzoxepin-5(2H)-ones and Related Compounds

Mannich bases derived from 3,4-dihydro-1-benzoxepin-5(2H)-ones, chromanones and 6,7,8,9-tetrahydrobenzocyclohepten-5(H)-one have been synthesised and shown to possess marked antiarrhythmic activity; 3,4-dihydro-7-methyl-4-(1-piperidinomethyl)- and 3,4-dih