80866-03-1Relevant academic research and scientific papers
Synthesis of N-Aryl-substituted 2-Aminoalkyl Ketones and 1,3-Alkanediamines
Barluenga, Jose,Cuervo, Humildad,Olano, Bernardo,Fustero, Santos,Gotor, Vicente
, p. 469 - 473 (2007/10/02)
4-Amino-1-azabutadienes (3-amino-2-alkenimines) react with Schiff bases to afford N,N-disubstituted 4-amino-1-azabutadienes.Both the starting and the product 4-amino-1-azabutadienes can be reductively cleaved with lithium aluminum hydride followed by hydr
β-Substituted Organolithium Compounds. Reaction with Alkyl Halides, Dimethyl Disulfide, and Imines
Barluenga, Jose,Fananas, Francisco J.,Villamana, Jorge,Yus, Miguel
, p. 1560 - 1564 (2007/10/02)
The reaction of β-substituted organolithium derivatives with several electrophiles leads to mono- as well as bifunctionalized organic compounds.Thus, by treatment of these dianions with alkyl halides a direct attack on the carbanionic carbon atom is performed, giving as a result substituted amines.When dimethyl disulfide is used, β-amino and β-hydroxy thioethers are obtained.Finally, on reaction with imines, 1-amino-3-hydroxy compounds and 1,3-diamines are obtained.Since these dianions are easily preparated by mercury-lithium transmetalation from β-substituted organomercurials resulting from the addition of mercury(II) salts to olefins, this whole process gives an appropriate way of functionalizing olefins.
