80866-87-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-2-phenyl-3,3,3-trifluoropropionitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its high reactivity allows for the creation of a wide range of organic compounds, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Methoxy-2-phenyl-3,3,3-trifluoropropionitrile serves as an essential intermediate for the production of various agrochemicals. Its role in the synthesis process aids in the development of effective crop protection products and other agricultural applications.
It is crucial to handle 2-Methoxy-2-phenyl-3,3,3-trifluoropropionitrile with care due to its potential health hazards upon exposure. Proper safety measures should be implemented during its use in both the pharmaceutical and agrochemical industries to ensure the well-being of workers and the environment.

InChI:InChI=1/C10H8F3NO/c1-15-9-5-3-2-4-7(9)8(6-14)10(11,12)13/h2-5,8H,1H3

Upstream product

• 108-86-1 bromobenzene 
• 434-45-7 2,2,2-Trifluoroacetophenone 
• 143-33-9 sodium cyanide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 55519-22-7 3,3,3-trifluoro-2-hydroxy-2-phenylpropanoic acid 
• 20445-31-2 MTPA 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 17257-71-5 (S)-Mosher acid 
• 105678-40-8 (2RS)-2-Methoxy-2-trifluoromethylphenylacetamide 
• 197386-30-4 3,3,3-trifluoro-2-methoxy-1,2-diphenylpropan-1-one 
• 197386-33-7 3,3,3-trifluoro-2-methoxy-1,2-diphenylpropanol 
• 197386-32-6 3,3,3-Trifluoro-1-(4-fluoro-phenyl)-2-methoxy-2-phenyl-propan-1-one 
• 197386-35-9 3,3,3-trifluoro-1-(4-fluorophenyl)-2-methoxy-2-phenylpropanol 
• 197386-31-5 3,3,3-Trifluoro-2-methoxy-1-(4-methoxy-phenyl)-2-phenyl-propan-1-one 
• 197386-34-8 3,3,3-trifluoro-2-methoxy-1-(4-methoxyphenyl)-2-phenylpropanol 
• 64312-89-6 Mosher's acid chloride 
• 20445-33-4 (+)-α-methoxy-α-(trifluoromethyl)phenylacetyl chloride 
• 39637-99-5 (-)-methoxytrifluoromethylphenylacetyl chloride 

Relevant academic research and scientific papers

A MODIFIED SYNTHESIS OF MOSHER'S ACID AND ITS USE IN A SENSITIVE STEREOISOMER ANALYSIS OF AMINO ACID DERIVATIVES

A convenient and sensitive method for stereoisomer analysis of amino acid derivatives is described.It is based on the (19)F NMR-analysis of mixtures containing epimers of N-.-methoxy-.-trifluoromethyl-phenylacetyl alanine (MTPA).An improved procedure for the synthesis of MTPA is given.

UTILISATION DE LA SYNTHESE ATROLACTIQUE POUR L'EVALUATION DE L'EFFICACITE D'INDUCTEURS DE SYNTHESE ASYMETRIQUE.

Atrolactic syntheses have been carried out to evaluate the potentiality, in asymmetric syntheses, of chiral inducers.The (d,l)-hydroxyhelicenes 1, 2, the (d,l) sec. alcohols 3-12 and the (d,l)phenolic binaphtyl compound 15 have been used as inducers.The d. e. are collected in table I (6-100 percent).The atrolactic asymmetric synthesis has also been carried out using three optically active inducers, namely: (-)-quinine 13, (-)-10,11-dihydroquinine 14, and R(-)-2,2,2-trifluoro-1-(9-anthryl)ethanol 6.Diastereomeric and enantiomeric excesses equal or greater than 88 percent have been obtained in six cases out of sixteen: (d,l)-2-hydroxyheptahelicene 1 (d. e = 100 percent +/-2), (1-naphtyl)-(9-anthryl)methanol 3 (d. e = 90 percent); 2,2,2-trichloro-1-(9-anthryl)ethanol 7 (d. e = 100 percent +/-2), 2,2,2-tribromo-1-(9-anthryl)ethanol 8 (d. e = 100 percent +/-2), (-)-quinine 13 (e. e = 95.5 percent), and (-)-2,2,2-trifluoro-1-(9-anthryl)ethanol 6 (e. e = 88 percent).

Determination of Enantiomeric Composition of Partly Racemized Carotenols

Method for determining enantiomeric composition of various racemized carotenols by converting them into diastereomeric esters with subsequent analysis have been studied.Diastereomeric esters of (-)-camphanic acid with carotenols other than α-ketols could not be separated by HPLC.No separation was achieved for diastereomeric esters of methoxytrifluoromethylphenylacetic acid (MTPA). 1H NMR analysis in the presence of Eu(fod)3 of diastereomeric MTPA esters allowed quantitative determination of the enantiomeric composition of carotenols with 2-hydroxy-β- and 3-hydroxy-β-type end groups.