808769-20-2

Usage

Uses

Used in Organic Synthesis:
3'-(Aminomethyl)biphenyl-4-ol is used as a building block in organic synthesis for its ability to serve as a precursor to more complex organic molecules. Its unique structure with an amino and hydroxyl group allows for versatile chemical reactions, facilitating the creation of a wide array of compounds.
Used in Pharmaceutical Research:
3'-(Aminomethyl)biphenyl-4-ol is used as a potential candidate in pharmaceutical research due to its aromatic structure and functional groups. These features may endow the compound with biological activities that could be harnessed for the development of new drugs, although further investigation is required to confirm its therapeutic potential.
Used in Chemical Intermediates:
In the chemical industry, 3'-(Aminomethyl)biphenyl-4-ol is used as an intermediate in the production of various specialty chemicals. Its reactivity and structural attributes make it suitable for the synthesis of dyes, pigments, and other chemical products that require its specific molecular framework.
Used in Material Science:
3'-(Aminomethyl)biphenyl-4-ol may also find applications in material science, where its structural properties could be leveraged to develop new materials with unique characteristics. For instance, it could be incorporated into the design of polymers, coatings, or composites that benefit from its chemical reactivity and stability.

InChI:InChI=1/C13H13NO/c14-9-10-2-1-3-12(8-10)11-4-6-13(15)7-5-11/h1-8,15H,9,14H2

Upstream product

• 865589-97-5 3'-(aminomethyl)biphenyl-4-ol hydrochloride 
• 154848-44-9 4'-hydroxy-3-biphenylcarbonitrile 
• 106-41-2 4-bromo-phenol 
• 150255-96-2 (3‐cyanophenyl)boronic acid 
• 808769-21-3 tert-butyl [(4'-hydroxybiphenyl-3-yl)methyl]carbamate 

Relevant academic research and scientific papers

Inhibitors of nedd8-activating enzyme

The invention relates to an administration unit comprising crystalline form I of {(1 S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate (I-216) hydrochloride salt and to a packaging comprising the administration unit according to the invention.

INTERMEDIATE AND PROCESS FOR THE PREPARATION OF A SULFONAMIDE DERIVATIVE

The invention relates to a crystalline form of 2-chloro-N-{2-[3-(2-{[(4'-hydroxybiphenyl-3- yl)methyl]amino}-2-oxoethyl)phenyl]-1,1-dimethylethyl}acetamide, a process for preparing the same and its use in the preparation of the ?2 agonist N-[(4'-hydroxybiphenyl-3- yl)methyl]-2-(3-{2-[((2R)-2-hydroxy-2-{4-hydroxy-3- [(methylsulfonyl)amino]phenyl}ethyl)amino]-2-methylpropyl} phenyl)acetamide which is useful in the treatment of respiratory diseases.

Development of an enabling route to PF-00610355: A novel inhaled β2-adrenoreceptor agonist

The initial route used to prepare PF-00610355 (8) for early clinical development is described. Through careful choice of solvent, an efficient, telescoped route to carboxylic acid 23 was developed, affording this late-stage intermediate in 80% yield over 4 steps. Deprotection of 23 to give sodium salt 24a and coupling with amine 6·HCl afforded the desired API. Effective synthetic routes to two of the starting materials, chiral bromide 1 and amine 6, are also described.

Sulfonamide derivatives for the treatment of diseases

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in

2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in