808771-71-3

Upstream product

• 3978-80-1 Boc-Tyr-OH 
• 617685-48-0 (S)-3-Phenyl-2-[((S)-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-propionic acid methyl ester 
• 500213-34-3 (S)-tert-butyl 3-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 115962-35-1 (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid 

Downstream Products

• 808771-90-6 C₆₂H₆₆N₆O₁₁ 
• 681254-34-2 2-benzyloxycarbonylamino-3-[2-({2-[2-{[1-(2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionyloxy]-butyric acid methyl ester 
• 681254-18-2 (2S,3R)-2-Benzyloxycarbonylamino-3-[(S)-2-({(S)-2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionyloxy]-butyric acid methyl ester 
• 808771-82-6 (S)-2-({(S)-2-[(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid methyl ester 
• 681253-58-7 (S)-2-({(S)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl}-amino)-3-phenyl-propionic acid 

Relevant academic research and scientific papers

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC

Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by

Novel antibiotics: Second generation macrocyclic peptides designed to trap Holliday junctions

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on th

A progressive synthetic strategy for class B synergimycins

Described are the syntheses of four macrocyclic peptides that are the core structure of class B synergimycins, and the synthesis of a final class B derivative. Our synthetic route to these synergimycin derivatives allows the incorporation of amino acid su