808771-92-8Relevant articles and documents
Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC
Pan, Po-Shen,Curtis, Fiona A.,Carroll, Chris L.,Medina, Irene,Liotta, Lisa A.,Sharples, Gary J.,McAlpine, Shelli R.
, p. 4731 - 4739 (2007/10/03)
Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by