80879-86-3

Basic information

• Product Name: 2,3-DIMETHYL-4-NITROANILINE
• Synonyms: 2,3-DIMETHYL-4-NITROANILINE;2,3-Dimethyl-4-nitrobenzenamine;4-Nitro-2,3-xylidine;2,3-Dimethyl-4-nitro-phenylamine
• CAS NO: 80879-86-3
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Mol File: 80879-86-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 116-117℃
• Boiling Point: 350.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.220±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.05±0.14(Predicted)
• CAS DataBase Reference: 2,3-DIMETHYL-4-NITROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHYL-4-NITROANILINE(80879-86-3)
• EPA Substance Registry System: 2,3-DIMETHYL-4-NITROANILINE(80879-86-3)

Safety Data

• Hazardous Substances Data: 80879-86-3(Hazardous Substances Data)

Usage

General Description

2,3-Dimethyl-4-nitroaniline is a chemical compound with the molecular formula C8H10N2O2. It is a yellow solid with a strong odor and is insoluble in water but soluble in organic solvents. 2,3-DIMETHYL-4-NITROANILINE is primarily used in the production of various dyes, including acid, azo, and direct dyes. It is also used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. However, 2,3-dimethyl-4-nitroaniline is considered to be toxic and may cause irritation to the skin, eyes, and respiratory system. It should be handled and used with appropriate safety precautions to avoid negative health effects.

InChI:InChI=1S/C8H10N2O2/c1-5-6(2)8(10(11)12)4-3-7(5)9/h3-4H,9H2,1-2H3

Upstream product

• 114166-32-4 2,3-dimethyl-4-nitroacetanilide 
• 7664-93-9 sulfuric acid 
• 87-59-2 2,3-Dimethylaniline 
• 134-98-5 N-(2,3-dimethylphenyl)acetamide 
• 138330-47-9 2,3-dimethyl-6-nitroacetanilide 

Downstream Products

• 101420-67-1 4-methyl-5-nitro-1H-indazole 
• 83-41-0 2,3-dimethylnitrobenzene 
• 5306-96-7 1,4-diamino-2,3-dimethylbenzene 
• 101421-63-0 1-bromo-2,3-dimethyl-4-nitro-benzene 
• 114166-32-4 2,3-dimethyl-4-nitroacetanilide 
• 343947-14-8 2,3-Dimethyl-4-nitro-benzenesulfonyl chloride 
• 285124-10-9 2,3-dimethyl-4-nitrophenyl isothiocyanate 
• 5628-44-4 amyldimethyl-para-aminobenzoic acid 
• 5628-45-5 4-Amino-2,3-dimethyl-benzoesaeure-methylester 
• 5628-61-5 4-methoxy-2,3-dimethyl-benzoic acid 
• 5628-62-6 4-Methoxy-2,3-dimethyl-benzoesaeure-methylester 
• 6021-31-4 4-hydroxy-2,3-dimethylbenzoic acid 
• 5628-56-8 methyl 2,3-dimethyl-4-hydroxybenzene-1-carboxylate 
• 90564-15-1 4-Nitro-2,3-dimethyl-benzoesaeure 

Relevant articles and documents

Design and synthesis of urea-linked aromatic oligomers-a route towards convoluted foldamers

Herein we report the design and synthesis of crescent-shaped and helical urea-based foldamers, the curvature of which is controlled by varying the constituent building blocks and their connectivity. These oligomers are comprised of two, three or five alternating aromatic heterocycles (pyridazine, pyrimidine or pyrazine) and methyl-substituted aromatic carbocycles (tolyl, o-xylyl or m-xylyl) connected together through urea linkages. A crescent-shaped conformational preference is encoded within these π-conjugated urea-linked oligomers based on intramolecular hydrogen bonding and steric interactions; the degree of curvature is tuned by the urea connectivity to the heterocycles and the aryl groups. NMR characterization of these foldamers confirms the intramolecular hydrogen-bonded conformation expected (Z,E configuration of the urea bond) in both the pyridazyl and pyrimidyl foldamers in solution. An X-ray crystal structure of the N3,N6-diisobutylpyridazine-4,6- diamine-o-tolyl urea-linked foldamer (4) confirms the presence of N-H...N hydrogen bonds between the heterocyclic nitrogen atom and the free hydrogen of the urea linkage. Additionally, the tolyl methyl group interacts unfavourably with the urea carbonyl oxygen, thus destabilising the alternate planar conformation.

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.