80896-22-6

Upstream product

• 19340-71-7 1-benzyl-4-phenyl-2-azetidinone 
• 17207-57-7 N-benzoyl-3-amino-3-phenylpropionic acid 
• 780-25-6 N-benzylidene benzylamine 
• 10387-40-3 potassium thioacetate 
• 78761-38-3 cinnamyl propionate 
• 100-46-9 benzylamine 
• 103-54-8 cinnamyl acetate 

Downstream Products

• 80896-31-7 N-benzyl-N-(3-hydroxy-1-phenyl-1-propyl)aminoacetonitrile 
• 80896-28-2 3-propionitrile 
• 80896-40-8 N-benzyl-N-(3-chloro-1-phenyl-1-propyl)aminoacetonitrile 
• 345208-85-7 1-benzyl-5-phenylpyrrolidine-2-carbonitrile 

Relevant academic research and scientific papers

Hydroamination versus Allylic Amination in Iridium-Catalyzed Reactions of Allylic Acetates with Amines: 1,3-Aminoalcohols via Ester-Directed Regioselectivity

In the presence of a neutral dppf-modified iridium catalyst and Cs2CO3, linear allylic acetates react with primary amines to form products of hydroamination with complete 1,3-regioselectivity. The collective data, including deuterium labeling studies, corroborate a catalytic mechanism involving rapid, reversible acetate-directed aminoiridation with inner-sphere/outer-sphere crossover followed by turnover-limiting proto-demetalation mediated by amine.

3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C-F or the like; R1 represents a C1-C3 alkyl group; Y represents oxygen atom or N-R7; R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, a C1-C6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library

Polymer-supported silyl enol ethers (thioketene silyl acetals) were prepared from chloromethyl copoly-(styrene-1%-divinylbenzene) resin. The silyl enol ethers reacted with imines in the presence of a catalytic amount of scandium triflate (Sc(OTf)3) to afford β-amino thioesters, which were reduced to amino alcohols in good yields. These reactions provide a convenient method for the preparation of an amino alcohol library.

Reduction of N-Substituted Azetidin-2-ones to Azetidines

Reduction of N-substituted azetidin-2-ones to N-substituted azetidines was accomplished rapidly and in good yield with diborane in tetrahydrofuran and with alane in ether.The stereochemistry of the ring substituents was retained under the reaction conditi

Synthesis of Phenyl- and Benzyl-Substituted Pyrrolidines and of a Piperidine by Intramolecular C-Alkylation. Synthons for Tricyclic Skeletons

The construction of new or novelly functionalized annulated and bridged tricyclic compounds by two consecutive C,C-bond formations (a and b in 1a, Scheme 1) is described.In a first step, Chloroalkyl-substituted aminonitriles yielded pyrrolidines 8, 15a, 1