80896-80-6Relevant academic research and scientific papers
Tricyclic indanyls as integrin inhibitors
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Page/Page column 21, (2010/02/10)
The present invention is directed to substituted indanyl compounds of Formula (I): Useful for treating integrin-mediated disorders such as, but not limited to unstable angina, thromboemboic disorders, osteoporosis, growth and metastasis of malignant tumors, diabetic retinopathy, arthritis, viral disease and surgical adhesions.
A concise synthesis of an indenopyrrolidine-based dual α vβ3/αvβ5 integrin antagonist
Luci, Diane K.,Santulli, Rosemary J.,Gauthier, Diane A.,Tounge, Brett A.,Ghosh, Shyamali,Proost, Jef C.,Kinney, William A.,De Corte, Bart,Galemmo Jr., Robert A.,Lewis, Joan M.,Dorsch, Warren E.,Wagaman, Michael W.,Damiano, Bruce P.,Maryanoff, Bruce E.
, p. 543 - 557 (2007/10/03)
A new class of dual αVβ3/α Vβ5 integrin antagonists containing a central cis-fused cyclopentane ring was identified. Because of its increased structural rigidity, the indenopyrrolidine ring system provides insight into the active conformation of other αVβ3 ligands. A concise synthesis of the indenopyrrolidine ring system was accomplished by 1,3-dipolar cycloaddition. Individual isomers of the most active compound were separated by chiral HPLC and their biological activities were compared.
Synthesis of Phenyl- and Benzyl-Substituted Pyrrolidines and of a Piperidine by Intramolecular C-Alkylation. Synthons for Tricyclic Skeletons
Achini, Roland
, p. 2203 - 2218 (2007/10/02)
The construction of new or novelly functionalized annulated and bridged tricyclic compounds by two consecutive C,C-bond formations (a and b in 1a, Scheme 1) is described.In a first step, Chloroalkyl-substituted aminonitriles yielded pyrrolidines 8, 15a, 1
