80898-77-7

Upstream product

• 68290-18-6 4-methylthio-2-azetidinone 
• 84089-26-9 p-nitrobenzyl 1-iodoacetate 

Downstream Products

• 80898-96-0 (2-Methylsulfanyl-4-oxo-azetidin-1-yl)-[4-oxo-[1,3]dithiolan-(2Z)-ylidene]-acetic acid 4-nitro-benzyl ester 
• 80898-94-8 [4-Hydroxy-4-methyl-[1,3]dithiolan-(2Z)-ylidene]-(2-methylsulfanyl-4-oxo-azetidin-1-yl)-acetic acid 4-nitro-benzyl ester 
• 80898-81-3 p-nitrobenzyl 2-[bis(acetylthio)methylidene]-2-(4-methylthio-2-azetidinon-1-yl)acetate 
• 80909-71-3 p-nitrobenzyl 2-(4-hydroxy-4-phenyl-1,3-dithiolan-2-ylidene)-2-(4-methylthio-2-azetidinon-1-yl)acetate 
• 80898-95-9 3-Carbamoylmethylsulfanyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 80898-97-1 (2-Chloro-4-oxo-azetidin-1-yl)-[4-oxo-[1,3]dithiolan-(2Z)-ylidene]-acetic acid 4-nitro-benzyl ester 
• 80898-93-7 7-Oxo-3-(2-oxo-propylsulfanyl)-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 80899-14-5 (2-Methylsulfanyl-4-oxo-azetidin-1-yl)-[4-oxo-[1,3]dithian-(2Z)-ylidene]-acetic acid 4-nitro-benzyl ester 
• 82834-81-9 (2-Chloro-4-oxo-azetidin-1-yl)-[4-hydroxy-4-methyl-[1,3]dithiolan-(2Z)-ylidene]-acetic acid 4-nitro-benzyl ester 
• 80899-13-4 3-(2-Carbamoyl-ethylsulfanyl)-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 82834-85-3 (2-Chloro-4-oxo-azetidin-1-yl)-[4-oxo-[1,3]dithian-(2Z)-ylidene]-acetic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

2-penem-3-carboxylic acid derivatives and use

Compounds of formula (I): STR1 in which: R1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups; R2 represents a hydrogen atom, a group of formula STR2 (in which R5 and R6 each represents an alkyl group, an aralkyl group or an aryl group, or R5 and R6 together represent a nitrogen-containing heterocyclic group) or a group of formula STR3 (in which R7 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted amino group, a cyclic amino group, a hydroxy group, an alkoxy group, an aryloxy group, an aralkyloxy group, a substituted or unsubstituted hydrazino group or a guanidino group, and A' represents a bivalent saturated aliphatic hydrocarbon group); and R3 represents a carboxy group or a protected carboxy group; and pharmaceutically acceptable salts thereof are valuable antibiotics and may be prepared from the corresponding 1-(protected carboxymethyl)-4-alkylthio-azetidin-2-one.