80902-08-5Relevant articles and documents
Direct monoalkylation of alkyl phosphinates to access H-phosphinic acid esters
Abrunhosa-Thomas, Isabelle,Ribiere, Patrice,Adcock, Alicia C.,Montchamp, Jean-Luc
, p. 325 - 331 (2007/10/03)
Simple alkyl phosphinates prepared by the silicate esterification method can be alkylated under Barbier-like conditions with butyl lithium at -78 °C followed by warming to room temperature. The method is limited to the more reactive electrophile such as allylic bromides and alkyl iodides. With these electrophiles good yields of H-phosphinic acid esters are generally obtained in a straightforward manner. Georg Thieme Verlag Stuttgart.
Prodrugs of NAALAdase inhibitors
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, (2008/06/13)
The present invention relates to prodrugs of NAALADase inhibitors, pharmaceutical compositions comprising the same, and methods of using the same to treat glutamate abnormalities and prostate diseases.
Inhibitors of NAALADase enzyme activity
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, (2008/06/13)
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated alpha -Linked Acidic Dipeptidase (NA
