80910-19-6

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 106-89-8 epichlorohydrin 
• 474097-67-1 2-<(cinnamyloxy)methyl>oxirane 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 93981-51-2 3-phenylpropyl alcohol allyl ether 
• 106-92-3 Allyl glycidyl ether 
• 591-50-4 iodobenzene 

Downstream Products

• 121508-92-7 N-{2-[2-Hydroxy-3-(3-phenyl-propoxy)-propylamino]-ethyl}-2-phenyl-acetamide 
• 80617-74-9 1-Isopropylamino-3-(3-phenyl-propoxy)-propan-2-ol 
• 80617-76-1 1-tert-Butylamino-3-(3-phenyl-propoxy)-propan-2-ol 
• 1192469-60-5 3-cyclohexylpropyl glycidyl ether 
• 1284299-62-2 C₁₅H₂₂O₃ 

Relevant academic research and scientific papers

Practical Intermolecular Hydroarylation of Diverse Alkenes via Reductive Heck Coupling

The hydroarylation of alkenes is an attractive approach to construct carbon-carbon (C-C) bonds from abundant and structurally diverse starting materials. Herein we report a palladium-catalyzed reductive Heck hydroarylation of aliphatic and heteroatom-substituted terminal alkenes and select internal alkenes with an array of (hetero)aryl iodides. The reaction is anti-Markovnikov selective with terminal alkenes and tolerates a wide variety of functional groups on both the alkene and (hetero)aryl coupling partners. Additionally, applications of this method to complex molecule diversifications are demonstrated. Mechanistic experiments are consistent with a mechanism in which the key alkylpalladium(II) intermediate is intercepted with formate and undergoes a decarboxylation/C-H reductive elimination cascade to afford the saturated product and turn over the cycle.

Oxidizing agent

PROBLEM TO BE SOLVED: To provide a novel compound useful as an oxidizing agent. SOLUTION: This invention relates to a compound represented by formula (I) [where each symbol is as defined in the specification] and a method for producing the same, and also relates to an oxidizing agent containing the compound. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

An Isolable and Bench-Stable Epoxidizing Reagent Based on Triazine: Triazox

A new triazine-based oxidizing reagent, 2-hydroperoxy-4,6-diphenyl-1,3,5-triazine (Triazox), has been developed. The reagent can be synthesized from inexpensive starting materials and is a bench-stable solid that is isolable in pure form. Epoxidation of alkenes possessing acid-sensitive functionalities using Triazox proceeded in good to excellent yields. The accompanying nonacidic triazinone coproduct can be easily removed by filtration. These features indicate that Triazox is a practically useful oxidizing reagent.

Rhodium nanoparticles supported on carbon nanofibers as an arene hydrogenation catalyst highly tolerant to a coexisting epoxido group

Rhodium nanoparticles supported on a carbon nanofiber (Rh/CNF-T) show high catalytic activity toward arene hydrogenation under mild conditions in high turnover numbers without leaching the Rh species; the reaction is highly tolerant to epoxido groups, which often undergo ring-opening hydrogenation with conventional catalysts.

Highly chemoselective hydrogenation with retention of the epoxide function using a heterogeneous Pd/C - Ethylenediamine catalyst and THF

In general, palladium-carbon (Pd/C) catalyzed hydrogenation of epoxides affords the corresponding primary and secondary alcohols as a mixture. It has been found that the catalytic activity of a Pd/C - ethylenediamine complex catalyst [Pd/C(en)] in the hydrogenolysis of epoxide functions is drastically reduced. Herein we describe a mild and chemoselective method for the hydrogenation of olefin, nitro, and azide functions with retention of the epoxide function. The chemoselectivity was accomplished by using a combination of 5% Pd/C(en) and THF as solvent. A significant drop in the chemoselectivity of the hydrogenation is observed with 5% Pd/C(en) in MeOH. These results reinforce the utility of epoxides as important precursors of alcohols in synthetic chemistry.

Thiazolidine and oxazolidine derivatives, their preparation and their medical use

Compounds of formula (I): STR1 and salts, esters and solyates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.