80912-51-2Relevant academic research and scientific papers
An efficient and scalable one-pot double Michael addition-Dieckmann condensation for the synthesis of 4,4-disubstituted cyclohexane β-keto esters
DeGraffenreid, Michael R.,Bennett, Sarah,Caille, Sebastien,De Turiso, Felix Gonzalez-Lopez,Hungate, Randall W.,Julian, Lisa D.,Kaizerman, Jacob A.,McMinn, Dustin L.,Rew, Yosup,Sun, Daqing,Yan, Xuelei,Powers, Jay P.
, p. 7455 - 7458 (2008/02/11)
(Chemical Equation Presented) A simple, scalable, and efficient one-pot methodology for the synthesis of 4,4-disubstituted cyclohexane β-keto esters from benzylic nitriles or esters and methyl acrylate promoted by potassium tert-butoxide is described. The process relies on a tandem double Michael addition-Dieckmann condensation reaction, which results in the formation of three discrete carbon-carbon bonds in a single pot, including a quaternary center. The method allows for the convenient and rapid synthesis of a variety of 4-aryl-4-cyano-2-carbomethoxycyclohexanone and 4-aryl-2,4- biscarbomethoxycyclohexanone building blocks for use in natural products synthesis and medicinal chemistry.
1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
-
, (2008/06/13)
Novel 1-[1-(4-aryl-cyclohexyl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-ones and 1-aryl-8-(4-aryl-cyclohexyl)-1,3,8-triazaspiro[4,5]decan-4-ones which are useful as antiemetic-and neuroleptic agents.
