80917-22-2

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 107071-31-8 2-t-butyl-4-(p-fluorophenyl)-6-phenylpyrylium trifluoromethanesulphonate 
• 122252-63-5 3-(4-Fluorophenyl)-6,6-dimethyl-2-(2-methyl-1-oxopropyl)-5-oxoheptanoic acid, ethyl ester 
• 122253-13-8 6-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-2-(1-methylethyl)-3-pyridinemethanol 
• 122253-36-5 3-Bromomethyl-6-tert-butyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine 
• 122252-77-1 6-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-2-(1-methylethyl)-3-pyridinecarboxylic acid, ethyl ester 
• 122254-62-0 (4R,6S)-6-{(E)-2-[6-tert-Butyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 122253-98-9 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[6-tert-butyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-ol 
• 122254-25-5 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[6-tert-butyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one 
• 122253-57-0 [6-tert-Butyl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide 
• 122253-78-5 6-tert-Butyl-3-{(Z)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-2-isopropyl-pyridine 
• 123930-20-1 6-tert-Butyl-3-{(E)-2-[(2S,4R,6R)-4-(tert-butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-4-(4-fluoro-phenyl)-2-isopropyl-pyridine 
• 107071-33-0 1-(p-bromobenzyl)-2-t-butyl-4-(p-fluorophenyl)-6-phenylpyridinium trifluoromethanesulphonate 
• 107071-34-1 2-t-butyl-4-(p-fluorophenyl)-6-phenylpyridine 

Relevant academic research and scientific papers

Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase

Here we report the first small-molecule inhibitors of human sulfide:quinone oxidoreductase (SQOR) that decrease the rate of breakdown of hydrogen sulfide (H2S), a potent cardioprotective signaling molecule. SQOR is a mitochondrial membrane-boun

Synthesis of Vicinal Quaternary All-Carbon Centers via Acid-catalyzed Cycloisomerization of Neopentylic Epoxides

We report our studies on the development of a catalytic cycloisomerization of 2,2-disubstituted neopentylic epoxides to produce highly substituted tetralins and chromanes. Termination of the sequence occurs via Friedel-Crafts-type alkylation of the remote (hetero)arene linker. The transformation is efficiently promoted by sulfuric acid and proceeds best in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent. Variation of the substitution pattern provided detailed insights into the migration tendencies and revealed a competing disproportionation pathway of dihydronaphthalenes.

ALLOSTERIC INHIBITORS OF ATYPICAL PROTEIN KINASES C

The invention provides specific small molecule compounds that allosterically regulate the activity of atypical protein kinase C, their use as a medicament, and their use in the treatment and prevention of allergic, inflammatory and autoimmune disorders, cancer, hyperproliferation, sepsis, viral and protozoan infections, dementing diseases, metabolic, sclerotic and osteoporotic disorders.

Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-χ

There is increasing evidence that the atypical protein kinase C, PKCχ, might be a therapeutic target in pulmonary and hepatic inflammatory diseases. However, targeting the highly conserved ATP-binding pocket in the catalytic domain held little promise to