809273-50-5Relevant academic research and scientific papers
Novel benzimidazole derivatives as selective CB2 agonists
Pagé, Daniel,Balaux, Elise,Boisvert, Luc,Liu, Ziping,Milburn, Claire,Tremblay, Maxime,Wei, Zhongyong,Woo, Simon,Luo, Xuehong,Cheng, Yun-Xing,Yang, Hua,Srivastava, Sanjay,Zhou, Fei,Brown, William,Tomaszewski, Miroslaw,Walpole, Christopher,Hodzic, Leila,St-Onge, Stéphane,Godbout, Claude,Salois, Dominic,Payza, Keymal
scheme or table, p. 3695 - 3700 (2009/04/04)
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.
BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF
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Page 28, (2008/06/13)
Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds ar
