809273-66-3

Upstream product

• 809273-65-2 (4,4-difluorocyclohexane)methylamine hydrochloride 
• 329-59-9 4-fluoro-3-nitro-benzoic acid methyl ester 

Downstream Products

• 809273-67-4 methyl 3-amino-4-{[(4,4-difluorocyclohexyl)methyl]amino}benzoate 
• 960390-74-3 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-cyclobutylpiperidine-4-carboxamide trifluoroacetate 
• 960390-76-5 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-isoxazol-3-ylpiperidine-4-carboxamide trifluoroacetate 
• 960391-08-6 N-[1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]cyclopropanecarboxamide trifluoroacetate 
• 960391-12-2 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-cyclopropylpiperazine-1-carboxamide trifluoroacetate 
• 960390-86-7 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-cyclopropylpyrrolidine-3-carboxamide trifluoroacetate 
• 960390-72-1 N-(tert-butyl)-1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxamide trifluoroacetate 
• 960391-14-4 2-tert-butyl-5-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole trifluoroacetate 
• 960391-06-4 2-[1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)azetidin-3-yl]-N-cyclopropylacetamide trifluoroacetate 
• 960390-64-1 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-ethylpiperidine-3-carboxamide trifluoroacetate 
• 960390-68-5 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-ethylpiperidine-4-carboxamide trifluoroacetate 
• 960390-70-9 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)-N-methylpiperidine-4-carboxamide trifluoroacetate 
• 960391-36-0 tert-butyl [1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidin-4-yl]carbamate 
• 960391-37-1 tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES WHICH ARE TO BE USED AS ANTAGONIST FOR THE CB1-RECEPTOR

Compounds of formula I or pharmaceutically acceptable salts thereof: wherein X, A, R1, R2, R3 and R4 are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

BENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM, PREPARATION THEREOF AND USES THEREOF

Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds ar