809278-68-0Relevant academic research and scientific papers
Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties
Kazmierski, Wieslaw M.,Andrews, Webb,Furfine, Eric,Spaltenstein, Andrew,Wright, Lois
, p. 5689 - 5692 (2007/10/03)
SAR around the HIV-1 protease inhibitor lead 4, which utilizes the (3S,5R)-3,5-bis(phenylmethyl)-2-pyrrolidinone as P1-P2 scaffold, led to discovery of meta-amino- and meta-hydroxy inhibitors 17b and 19b, which while equipotent to 4, in addition offered a
