80928-52-5Relevant academic research and scientific papers
Total synthesis of vineomycin B2
Kusumi, Shunichi,Tomono, Satoshi,Okuzawa, Shunsuke,Kaneko, Erika,Ueda, Takashi,Sasaki, Kaname,Takahashi, Daisuke,Toshima, Kazunobu
, p. 15909 - 15912 (2013)
The first total synthesis of vineomycin B2 (1) has been accomplished. The aglycon segment, a vineomycinone B2 derivative, and the glycon segment, an α-l-acurosyl-l-rhodinose derivative, were prepared via C-glycosylation using an unprotected sugar and powerful chemoselective O-glycosylation using a 2,3-unsaturated sugar, respectively, as the key steps. Furthermore, effective and simultaneous introduction of the two glycon moieties to the aglycon part by concentration-controlled glycosylation led to the total synthesis of 1.
Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety
Zhang, Yun,Huang, Hongbo,Chen, Qi,Luo, Minghe,Sun, Aijun,Song, Yongxiang,Ma, Junying,Ju, Jianhua
supporting information, p. 3254 - 3257 (2013/07/26)
The gene cluster responsible for grincamycin (GCN, 1) biosynthesis in Streptomyces lusitanus SCSIO LR32 was identified; heterologous expression of the GCN cluster in S. coelicolor M512 yielded P-1894B (1b) as a predominant product. The ΔgcnQ mutant accumulates intermediate 1a and two shunt products 2a and 3a bearing l-rhodinose for l-cinerulose A substitutions. In vitro data demonstrated that GcnQ is capable of iteratively tailoring the two l-rhodinose moieties into l-aculose moieties, supporting divergent roles of GcnQ in different hosts.
